A Novel Prodrug Strategy to Treat Prostate Cancer by Targeting MYC-Driven Nucleotide Biosynthesis

Abstract

Over the research period, a significant synthesis effort was underway to access proposed synthetic analogs of ribose-5-phosphate. The effort included execution of the two proposed synthetic approaches, which did not yield positive results and a design and execution of a new promising approach, which did yield one of the proposed analogs.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1060304

Entities

People

  • Matthew Parker

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Anabolism
  • Biological Sciences
  • Biomedical Research
  • Bromine
  • California
  • Cecum
  • Chemical Compounds
  • Chemistry
  • Complex Mixtures
  • Department Of Defense
  • Ethylene Glycol
  • Fluorination
  • Halogenation
  • Information Operations
  • Maryland
  • Neoplasms
  • Organic Compounds
  • Professional Development
  • Prostate
  • Prostate Cancer
  • Standards
  • Targeting
  • Technology Transfer
  • Urban Areas

Fields of Study

  • Chemistry
  • Computer science

Readers

  • Computational Modeling and Simulation
  • Molecular Genetics
  • Oncology (Cancer Research).