Real-Time Detection of Cellular Respiratory Bio-Markers of Early-Stage Infections Using Terahertz Sensing

Abstract

Early detection and prevention of respiratory infections is a critical mission of military and civilian medical facilities. For example, adenoviruses are a major cause of acute respiratory illness in the military. The hypothesis that different types of cells produce unique profiles of respiratory chemicals (gaseous biomarkers) is substantiated by apparent differences in cell-specific metabolic biochemistry. The research team comprised of Drs. Ivan Medvedev (WSU-Physics), Katherine Excoffon (WSU-Biology), and Jennifer Martin (AFRL) is studying the variability of respiratory chemical profiles for a variety of cellular species, as well as a range of metabolic, homeostatic, and infectious conditions. The analysis is done using THz chemical sensing facility at WSU and Gas Chromatography-Mass Spectrometry (GC-MS) facility at AFRL. We are studying variability of respiration associated with viral infections (such as adenovirus).

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2018
Accession Number
AD1060305

Entities

People

  • Ivan R. Medvedev
  • Jennifer Martin
  • Katherine Excoffon

Organizations

  • Wright State University

Tags

DTIC Thesaurus Topics

  • Adenoviruses
  • Alcohols
  • Biochemistry
  • Biological Markers
  • Biomedical Research
  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Data Analysis
  • Detection
  • Detectors
  • Epithelial Cells
  • Experimental Design
  • Gas Chromatography
  • Infection
  • Mass Spectrometry
  • Measurement
  • Medical Personnel
  • Metabolism
  • Spectra
  • Spectrometers
  • Spectrometry
  • Spectroscopy
  • Three Dimensional
  • Wound Infections

Readers

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  • Analytical Chemistry
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