Regional Anesthesia and Valproate Sodium for the Prevention of Chronic Post-Amputation Pain

Abstract

This research was designed to test the efficacy of valproic in reducing the incidence of chronic pain after amputation, and to elucidate the underlying epigenetic mechanisms. We have completed the randomized controlled trial at Duke University, WRNMMC, and the Durham VAMC. All patients received multimodal perioperative care including regional anesthesia and were randomized to valproic acid or placebo. Our data reveal an overall rate of chronic pain of 68.22 % without a significant effect of valproic acid. The incidence of chronic pain was 65.45 % in the treatment group and 71.15 % in the placebo group.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1060310

Entities

People

  • Thomas E. Buchheit

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Anesthesia
  • Anticonvulsants
  • Antidepressants
  • Chemical Synthesis
  • Chemotherapy
  • Drug Abuse
  • Health Services
  • Institutional Review Board
  • Liver Diseases
  • Medical Personnel
  • Neuromuscular Diseases
  • Pain
  • Pain Management
  • Patient Care
  • Pharmacies
  • Residual Limbs
  • Statistical Analysis
  • Surgery
  • Surgical Amputations
  • Therapy
  • Vascular Diseases

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.