Manganese Research Health Project (MHRP)
Abstract
Inhalation of high manganese (Mn) concentrations may result in serious irreversible neurological disease (manganism). The air exposure level associated with an increased risk of acquiring subtle neurological disturbances is currently not known. Welding fumes contain Mn. In this study 332 subjects have been examined with neurobehavioral methods, of whom 137 are currently exposed welders and 137 are referents. Among these, 63 welders and 65 referents were examined with the same methods around six years earlier. Also 34 patients diagnosed with manganism (17 also examined six years earlier) and 25 withidiopathic Parkinsons disease (PD) were examined. Positron Emission Tomography examinations were carried out in eight PD-patients, eight manganism cases and six referents. The laboratory analyses of the biological samples and personal welding fume samples have been completed. Currently the statistical work is being carried out. The scientific publication process has started.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2012
- Accession Number
- AD1060394
Entities
People
- Michael Aschner
Organizations
- Vanderbilt University