Manganese Research Health Project (MHRP)

Abstract

Inhalation of high Manganese (Mn) concentrations may result in serious irreversible neurological disease (manganism). The air exposure level associated with an increased risk of acquiring subtle neurological disturbances is currently not known. Welding fumes contain Mn. In this study 322 subjects have been examined with neurobehavioral methods, of whom 137 are currently exposed welders and 137 are also referents. Among these, 63 welders and 65 referents were examined with the same methods around six years earlier. Also 34 patients diagnosed with manganism (17 also examined six years earlier) and 25 with idiopathic Parkinson's disease (PD) were also examined. Positron Emission Tomography examinations were carried out in eight PD-patients, eight manganism cases and six referents. Currently the results from the study are under publication. The first paper was published this year. A second manuscript will probably be submitted during March 2013.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2013
Accession Number
AD1060395

Entities

People

  • Dag G Ellingsen
  • Michael Aschner

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Alcohol Consumption
  • Biological Markers
  • Biomedical Research
  • Composite Materials
  • Contracts
  • Department Of Defense
  • Diseases And Disorders
  • Education
  • Elements
  • Environmental Monitoring
  • Health Care
  • Health Services
  • Human Factors Engineering
  • Information Science
  • Isotopes
  • Linear Regression Analysis
  • Manganese
  • Nervous System
  • Neurodegeneration
  • Parkinson Disease
  • Parkinson'S Disease
  • Physical Disabilities
  • Positron Emission Tomography
  • Positron Emissions
  • Regression Analysis
  • Sampling
  • Solubility
  • South Africa
  • Statistical Analysis

Fields of Study

  • Medicine

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