Control of Atherosclerosis Regression by PRMT2 in Diabetes

Abstract

Diabetics have more heart disease than their non-diabetic counterparts, even though drugs like Lipitor are equally effective in both groups at lowering the blood levels of harmful cholesterol. We propose to understand why comparable reductions in harmful cholesterol are less effective in diabetics. We have identified an enzyme called PRMT2, which regulates the abundance of a cellular cholesterol transporter that helps to prevent cells from accumulating in arteries and forming a plaque. We have shown that the level of PRMT2, while high in healthy cells, is very low in cells from diabetics when blood sugar levels are elevated.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1060403

Entities

People

  • Michael Garabedian

Organizations

  • New York University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Bone Marrow
  • Bones
  • Cell Line
  • Cells
  • Cholesterol
  • Diseases And Disorders
  • Gene Expression
  • Health Services
  • Heart Diseases
  • Macrophages
  • Mass Spectrometry
  • Medical Personnel
  • New York
  • Steady State
  • Vascular Diseases

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Optical Fiber Sensing and Electromagnetic Propagation.