Diacylglycerol Activation of T Cell Receptor Signaling for Cancer Immunotherapy
Abstract
We have accomplished all of our goals and milestones outlined in Year 1 of the statement of work, which has resulted in 3 peer-reviewed publications and 6 conference abstract to disseminate our research findings. As part of our research efforts, 2 of my senior graduate students received vital career development opportunities at prestigious national meetings. Our findings have impacted the chemistry and cancer immunology field by identifying novel druggable sites of diacylglycerol kinases (DGKs), which are exciting new drug targets for immuno-oncology in melanoma. We identified a lead fragment molecule (RF001) that will serve as the starting point for developing potent and selective DGK inhibitors. The broader impacts of our findings is to inform the general public on the significance of fat metabolism, which is greatly influenced by food choices in society, in our immune systems ability to fight cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2018
- Accession Number
- AD1060435
Entities
People
- Hsu Ku-lung