Chemokine Based Therapy for Post-Traumatic Osteoarthritis

Abstract

Injuries causing ruptures to the anterior cruciate ligament (ACL) are a common cause of posttraumatic osteoarthritis (PTOA)Since Duffy antigen receptor for chemokines (DARC) binds inflammatory chemokines previously shown to be up-regulated in osteoarthritic knees, we proposed to analyze the role of DARC on the development of PTOA in the present study. The mRNA levels of two major inflammatory cytokines Il-6, Il-1 were up-regulated as early as at one-day post-ACL injury. While no effect was observed in the mRNA level of Rantes in response to ACL injury. Mcp-1 mRNA was increased at one-day post-ACL injury in Darc-KO and wild type mice but the magnitude of increase was greater in Darc-KO compared to WT mice at one-day post-ACL injury. Among the three Mmps tested in this study, only Mmp3 showed significant increase in mRNA level in response to ACL injury during the first week post-ACL injury in both lines of mice.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2018
Accession Number
AD1060883

Entities

People

  • Bouchra Edderkaoui

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Arthritis
  • Biomedical Research
  • Cartilage
  • Cells
  • Cytokines
  • Gene Expression
  • Inflammation
  • Joints (Anatomy)
  • Leg Injuries
  • Ligaments
  • Medical Personnel
  • Military Personnel

Fields of Study

  • Medicine

Readers

  • Immunology
  • Molecular Biology and Genetics
  • Neurotrauma and Rehabilitation Medicine.