Chronic Intermittent Hypoxia-Induced Neuroinflammation Undermines Respiratory Motor Plasticity After Chronic Incomplete Cervical Spinal Cord Injury

Abstract

The goal of this project is to determine the impact of chronic intermittent hypoxia, a primary feature of sleep apnea, on respiratory recovery and plasticity following chronic cervical spinal cord injury (SCI). Prior work has shown that chronic intermittent hypoxia can trigger neuroinflammation and impair expression of respiratory plasticity. This this work has important clinical applications in SCI, since the prevalence of sleep apnea is much higher in than the uninjured population. Thus it raises concern that individuals with chronic SCI who also suffer from sleep apnea may have limited potential for plasticity and recovery of breathing function, if underlying inflammation is not addressed.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2018
Accession Number
AD1060897

Entities

People

  • Elisa J. Gonzalez-rothi

Organizations

  • University of Florida

Tags

DTIC Thesaurus Topics

  • Department Of Defense
  • Diseases And Disorders
  • Inflammation
  • Medical Personnel
  • Neurology
  • Neurophysiology
  • Physiology
  • Professional Development
  • Recovery
  • Respiration
  • Spinal Cord
  • Spinal Injuries
  • Students
  • Terminals
  • Therapy
  • Training
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neurotrauma and Rehabilitation Medicine.