CLMP-Mediated Regulation of Intestinal Homeostasis in IBD
Abstract
The intestinal mucosa is lined by a single layer of epithelial cells (IECs) that form a selective physical barrier allowing the passage of nutrients while protecting the body against external antigens. Impairment of the intestinal barrier is associated with uncontrolled infiltration of leukocytes into the gut mucosa and represents a hallmark of inflammatory bowel disease (IBD). CAR-Like Membrane Protein (CLMP) belongs to the Cortical Thymocyte marker in Xenopus (CTX) family. CTX members are single transmembrane proteins that have been reported to play a role in epithelial barrier function and leukocyte recruitment to inflammatory sites.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2018
- Accession Number
- AD1060903
Entities
People
- Anny-claude Luissint
- Asma Nusrat
- Charles A. Parkos
Organizations
- University of Michigan