Tau Pathology as a Contributor to Gulf War Illness and a Basis for Potential Therapy

Abstract

The study plan is to differentiate the hiPSCs, which were derived from Gulf War (GW) veterans with Gulf War Illness (GWI) and healthy control veterans without GWI, into neurons, and to use these neurons as models to probe for tau pathologies when they are exposed to the GWI toxicants (Cortisol DFP). Also, we want to see if reduction of tau or inhibition of tauphosphorylation helps alleviate the pathological changes. For the two-year proposed study, the first year has been devoted to differentiating the hiPSCs, investigating tau related pathological phenotypes and examining the morphological changes and microtubule deficit among the hiPSC derived neurons from both control and GWI cases when exposed to cortisol DFP.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1060911

Entities

People

  • Kimberly Sullivan
  • Liang Qiang
  • Peter W Baas

Organizations

  • Drexel University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Cells
  • Cortisol
  • Cytoskeleton
  • Diseases And Disorders
  • Electronic Mail
  • Information Processing
  • Management Personnel
  • Medical Personnel
  • Mitochondria
  • Nerve Agents
  • Pathology
  • Persian Gulf Syndrome
  • Pesticides
  • Phenotypes
  • Phosphorylation
  • Students

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and Cellular Biology
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.