The Epigentic Changes of Adverse Childhood Experience, Combat Exposure, and Post Traumatic Stress Disorder in Active Duty Service Members

Abstract

Since 9/11 1.64 million soldiers deployed. 50% experienced traumatic events, Friends killed, Seeing dead/ injured non-combatants, Witnessing accidents leading to individuals death, Smelling decomposing bodies. Of subset, 300,000 are projected to meet diagnosis criteria of PTSD*: Direct and indirect cost of care is $25,757 perindividuals in the first two years of deployment. Increased risk of psychiatric comorbidities, domesticviolence, family strain, and homelessness. Combat PTSD is complex likely involving multiple riskfactors and multiple pathophysiologies. Risk factors: Adult traumatic even (combat), Childhood adversity. Genetic risk factors (SLC6A4) Environment x Genetics (Multiple SNPs)Pathophysiologies, and Methylations changes. Autonomic pathologies

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Document Details

Document Type
Technical Report
Publication Date
Aug 20, 2018
Accession Number
AD1061574

Entities

People

  • Adam M. Willis

Organizations

  • 59th Medical Wing

Tags

DTIC Thesaurus Topics

  • Active Duty
  • Air Force
  • Antidepressants
  • Anxiety Disorders
  • Brain
  • Brain Injuries
  • Diseases And Disorders
  • Genes
  • Genetics
  • Medical Personnel
  • Military Medicine
  • Military Personnel
  • Pathophysiology
  • Proteins
  • Risk Factors
  • Traumatic Stress Disorder
  • United States Government

Fields of Study

  • Medicine
  • Psychology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Molecular and genetic basis of cancer.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.

Technology Areas

  • Biotechnology