Validation of Structural, Molecular, and Functional Imaging Biomarkers in Spinal Cord Injury in Non-Human Primates

Abstract

Spinal cord injuries (SCI) impair sensory, autonomic and/or motor functions, and area leading cause of disability. The process of spontaneous repair of damaged SC is poorly understood because of a lack of appropriate longitudinal tracking methods. Such a method would provide the information needed for a basic understanding of recovery processes and for determining the optimal time window, targets and effectiveness of therapeutic interventions. Combinations of novel, advanced MRI methods can provide unique insights into SCI progression, especially into the functional integrity of grey matter and micro-structural and biochemical changes in white matter. Much previous work in rodent models has limited significance for human injuries, but studies in non-human primates are directly applicable. We propose to use non-invasive multiparametric MRI at high field to assess changes in structural, functional and cellular/molecular properties of SCI over time in a monkey model and determine how these changes predict and correlate with behavioral recovery.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1061764

Entities

People

  • John C. Gore

Organizations

  • Vanderbilt University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Algorithms
  • Biological Markers
  • Data Acquisition
  • Data Analysis
  • High Resolution
  • Histological Techniques
  • Medical Personnel
  • Nervous System
  • Power Spectra
  • Professional Development
  • Recovery
  • Rodents
  • Spinal Cord
  • Spinal Injuries
  • United States
  • Validation

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.
  • Systems Analysis and Design