Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy

Abstract

During the second funding period we partially fulfilled Major Task 3. The degree of lymphocyte infiltration was assessed in premalignant (n = 328) and malignant lesions (n = 15AIS and 50 ADC), along with adjacent histologically normal areas (n = 50) in lobectomy specimens from 41 patients who had undergone surgery for early stage ADC. Lymphocyte infiltration was graded 0-to-3 based on H and E staining and was significantly increased in AAHvs. normal areas and became highest in AIS and ADC. Expression of regulators of cell-mediated immunity, including CD4, CD8, FOXP3, PD-1 and PD-L1 was quantified in AAH and ADC in a subset of 9 cases by immunohistochemistry. Quantitative multiplex immunofluorescent staining for 8immune markers in the entire study cohort (41 cases) is ongoing and will be completed during the No Cost Time Extension.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2018
Accession Number
AD1061765

Entities

People

  • Kostyantyn Krysan

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Biological Staining And Labeling
  • Biomedical Research
  • Cancer
  • Cells
  • Data Analysis
  • Demographic Cohorts
  • Department Of Defense
  • Electronic Mail
  • Gene Expression
  • Immune System
  • Immunity
  • Lung Cancer
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Regulators

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Oncology
  • Oncology and Biomarker-Based Cancer Detection.