Molecular Signature of Acute Rejection in Clinical Face Transplants

Abstract

Vascularized composite allotransplantation (VCA), such as face and limb transplantation, is life transforming. Immunosuppression following VCA transplantation is based on protocols used in solid organ transplantation, but it is unclear if this is appropriate. The aims of this project are to i) determine the molecular phenotype of human face transplant rejection, ii)compare gene expression profiles of facial transplant rejection with that of inflammatory dermatoses, iii) compare gene expression profiles of facial transplant rejection with publically available gene expression datasets in solid organ transplants. We hypothesize that there are unique as well as shared molecular features in face transplant rejection compared to solid organ transplant rejection. Determination of unique features of face transplant rejection will highlight the need for and facilitate the development of targeted therapies for VCA recipients.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1061775

Entities

People

  • Bohdan Pomahač

Tags

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Composite Materials
  • Data Analysis
  • Gene Expression
  • Genes
  • Health Services
  • Local Governments
  • Materials
  • Medical Personnel
  • Patent Applications
  • Phenotypes
  • Professional Development
  • Training
  • Transplantation
  • Transplants

Fields of Study

  • Biology

Readers

  • Neuroscience

Technology Areas

  • Biotechnology