Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

Abstract

We are interested in determining whether ambient air pollutants impact the development of Parkinson's disease (PD) by increasing -synuclein pathology via inflammation. In this aim we injected alpha -synuclein (alpha-syn) pre-formed fibrils (PFF) in the right olfactory bulbs of mice to model PD then exposed them to nano-particulate matter (nPM) for four weeks after injections. Ten weeks later, we euthanized the mice. The Brundin lab confirmed that PFF injections induced the expected phosphorylated -syn pathology throughout olfactory areas. nPM exposure increased phosphorylated -syn pathology only in the cortical amygdala. Importantly, we determined that nPM exposure did not show the expected increase of inflammatory or oxidative markers suggesting that these nPM effects may have been resolved during this extended period of time (10 weeks) when mice were not exposed to nPM.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1061910

Entities

People

  • Caleb E. Finch

Organizations

  • University of Southern California

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Pollutants
  • Air Pollution
  • Alzheimer Disease
  • Brain
  • California
  • Cognition
  • Dementia
  • Department Of Defense
  • Diseases And Disorders
  • Inflammation
  • Medical Personnel
  • Parkinson'S Disease
  • Particles
  • Particulate Matter
  • Particulates
  • Pathology

Readers

  • Immunology and Pathology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.