Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

Abstract

We are interested in determining whether ambient air pollutants impact the development of Parkinson's disease (PD) by increasing -synuclein pathology via inflammation. In this aim we injected -synuclein (-syn) pre-formed fibrils (PFF) in the right olfactory bulbs of mice to model PD then exposed them to nano-particulate matter (nPM) for four weeks after injections. Ten weeks later, we euthanized the mice. We first confirmed that PFF injections induced the expected phosphorylated -syn pathology throughout olfactory areas, and we are presently determining whether nPM exposure worsened that pathology via neuroinflammation. In summary, we observe increased phosphorylated -syn pathology in the cortical amygdala after nPM exposure.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1061918

Entities

People

  • Patrik Brudin

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Pollutants
  • Airborne
  • Biological Staining And Labeling
  • Biomedical Research
  • Brain
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Medical Personnel
  • Neurons
  • Parkinson'S Disease
  • Particles
  • Particulate Matter
  • Particulates
  • Pathology
  • Professional Development

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Neuroscience
  • Toxicology/Environmental Toxicology