Intra-Articular Lubricin Gene Therapy for Post-Traumatic Arthritis

Abstract

This project focuses on addressing cartilage lubricant failure in post-traumatic osteoarthritis (PTOA) via intra-articular lubricin/proteoglycan 4 (PRG4) gene therapy. Our findings thus far indicate that a single intra-articular injection of adeno-associated virus (AAV) bearing the PRG4 gene in a rabbit ACL transection (ACLT) model resulted in transgene expression until the end-point of the experiment at 8 weeks post-op, and that the injection treatment was chondroprotective. PRG4 gene therapy appears to be a viable option for slowing the progression of PTOA, a finding that warrants investigation of the strategy in a large animal model. Accordingly we applied for a PRMRP Focused Program Award (FPA),which includes a project to pursue lubricin gene therapy in a Yucatan Minipig intra-articular fracture model. The proposal was recently.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1061927

Entities

People

  • James A. Martin

Organizations

  • University of Iowa

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Addressing
  • Arthritis
  • Biological Staining And Labeling
  • Biomedical Research
  • Bone Fractures
  • Cartilage
  • Confocal Microscopy
  • Data Analysis
  • Department Of Defense
  • Electronic Mail
  • Gene Therapy
  • Histology
  • Medical Personnel
  • Students
  • Surgery
  • Therapy

Fields of Study

  • Medicine

Readers

  • Molecular Genetics
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology