Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

Abstract

This proposal aims to investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (>6 months post-injury). Our central hypothesis is that cervical SCI is associated with frequent episodes of hypoxia, resulting in chronic intermittent hypoxia (CIH), recurrent arousals from sleep, and increased peripheral chemoreceptor activity. To test our central mechanistic hypothesis, we propose a series of experiments to investigate the following Specific Aims: (1): To test the hypothesis that patients with cervical SCI will demonstrate greater magnitude of LTF following EH during sleep, compared to patients with thoracic SCI.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1062513

Entities

People

  • M S Badar
  • Sarah Vaughan

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Air Pressure
  • Biomedical Research
  • Chemoreceptors
  • Clinical Trials
  • Data Analysis
  • Diseases And Disorders
  • Measurement
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Quality Of Life
  • Respiration
  • Respiration Disorders
  • Serotonin Agents
  • Spinal Cord
  • Spinal Injuries
  • Spine

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Circadian Sleep-Wake Regulation and Chronobiology
  • Neurotrauma and Rehabilitation Medicine.