Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss
Abstract
In this study, we are examining the efficacy of a potential early intervention therapeutic for noise induced hearing loss (NIHL).The generation of reactive oxygen species is one of the underlying mechanisms of noise-induced damage to tissues in the innerear that leads to noise-induced hearing loss (NIHL). The goal is to define an effective post-exposure, non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss: mitochondrial dysfunction and overproduction of reactive oxygen species. Utilizing a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the tissues of the inner ear resulting from a single acute sound exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1062928
Entities
People
- Alfred L. Nuttall
Organizations
- Oregon Health & Science University