Sigma-1 Receptor Agonists as a Novel Therapeutic for Brain Mitochondrial Dysfunction in Gulf War Syndrome

Abstract

Gulf War Syndrome or Illness (GWI) is a unique chronic health disorder with multiple symptoms including cognitive difficulties, fatigue, muscular pain, and gastrointestinal problems. GWI is believed to be associated with prolonged or excessive exposure to various pesticides and pyridostigmine bromide (PB). This toxicant exposure causes disrupted mitochondrial function in neurons and thus cognitive difficulties in GWI. Treatments that target at restoring mitochondrial function in neurons and improving cognitive abilities in GWI veterans are needed. Sigma-1 receptor (S1R) agonists have the potential to restore mitochondrial function. This study will test therapeutic efficacy of selected S1R agonists for cognitive difficulties in an established GWI mouse model.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1062931

Entities

People

  • Kai Shen
  • Meharvan Singh

Organizations

  • Savannah State University

Tags

DTIC Thesaurus Topics

  • Behavioral Sciences
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare Agents
  • Contracts
  • Culture Techniques
  • Department Of Defense
  • Diseases And Disorders
  • Dysfunction
  • High Resolution
  • Management Personnel
  • Maryland
  • Medical Personnel
  • Metabolism
  • Neurons
  • Oligomers
  • Persian Gulf Syndrome
  • Pesticides
  • Professional Development
  • Proteins
  • Pyridostigmine Bromide
  • Recombinant Proteins
  • Social Sciences
  • Students
  • Therapy
  • Tissue Culture
  • Universities

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neuroscience