Cortical Photostiumlation Technology for Vision Prosthesis
Abstract
The overall goal of the project is to evaluate the feasibility of using photochemical stimulation of cortical neurons as the basis for a visual prosthesis. Accomplishments during year 2 of the project include: 1) production of oxNI-Glu, the caged glutamate compound, for in vivo toxicological and in vitro physiological studies; 2) completion of toxicological studies showing that chronic infusion of oxNI-Glu into mouse cortex is benign and well-tolerated; 3) in vitro photoactivation tests in mouse brain slices showing that focal photolysis of oxNI-Glu in situ can photoactivate cortical neurons reliably; and 4) successful training of mice in an automated operant conditioning cage to exhibit conditioned behavior in response to a stimulus.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2018
- Accession Number
- AD1062932
Entities
People
- Joseph P. Kao
Organizations
- University of Maryland, Baltimore