Targeting Metastatic Prostate Cancer with Tumor-Specific Marrow Infiltrating-Lymphocytes (MILs)
Abstract
Though T-cells in prostate cancer are characterized by an exhausted and suppressive state, the bone marrow represents a documented reservoir of polyclonal antigen-experienced memory T-cells, including clones with anti-tumor specificity, coined marrow-infiltrating lymphocytes or MILs. Memory cells are naturally enriched in the bone marrow due to the unique attributes of this compartment. Thus, despite being initially counter-intuitive, the bone marrow represents a robust source of tumor-specific memory T-cells even in patients with no tumor burden in the bone marrow. Of note, memory T-cells are associated with superior engraftment, increased proliferative potential, greater persistence, and enhanced anti-tumor activity; all of which lead to improved clinical outcomes and longer survival in patients undergoing adoptive cell therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2018
- Accession Number
- AD1063062
Entities
People
- Nathaniel Brennen
Organizations
- Johns Hopkins University