Liquid Chromatography Tandem Mass Spectrometry in Toxicology and Environmental Sciences Research and Education Programs
Abstract
The purpose of this proposal was to seek a matching fund to acquire a liquid chromatography tandem mass spectrometry (LC-MSMS) instrument for John Jay College, a senior college within the City University of New York and a Minority-Serving Institution, to enhance its research capabilities and improve its educational program. Thanks to this award, the equipment ultra-fast liquid chromatograph Nexera, UFLC-XR coupled to a triple quadrupole mass spectrometer (LCMS-8050) from Shimadzu Corporation was installed in the Toxicology Laboratory in John Jay College in September 2016. The installation was completed on September 8th 2016, and the PI Marta Concheiro-Guisan and the co-PIs Shu-Yuan Cheng and Yi He attended the corresponding training on September 12th, 19th and 21st 2016. Since then, the equipment has been employed in undergraduate and graduate projects in Human Performance and Biosystems and Environmental Chemistry research areas. A total of 3 undergraduate students and 4 graduate students have been utilizing this instrument in their corresponding research projects. The main problem studied with the equipment since its installation has been the waste-water analysis of tobacco and illicit drugs in New York City. Wastewater-based toxicology is an innovative and promising approach that provides information about exposure to external agents, such as drugs of abuse and medicines, in defined population groups by the analysis of human excretion products (biomarkers) in wastewater. Traces of almost everything we consume are excreted unchanged or as a mixture of metabolites in our urine and/or feces and ultimately end up in the sewer network (1). This approach is best described as large urine test, as the collective wastewater represents anonymous urine samples of thousands of individuals. By measuring the levels of licit and illicit drugs and their metabolites in wastewater, the quantity of drugs consumed in a community can be estimated (2).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 2017
- Accession Number
- AD1063245
Entities
People
- Marta Concheiro-guisan
- Shu Y Cheng
- Yi He
Organizations
- Research Foundation of The City University of New York