The Imprint of Psychogenic Non-Epileptic Seizures on the Brain: A New Model and Imaging Biomarker

Abstract

The goal of the project is to obtain evidence that supports a new mechanism that assumes that PNES are caused by a predisposition for enhanced synchronization/overshooting recruitment of brain regions involved in emotion control/processing of traumatic/stressful experiences. By assuming such a predisposition, the project implicitly assumes that PNES have a specific biological underpinning. The first year of the project was spent on finalizing questionnaires and report forms , obtaining IRB approval from all participating institutions, development and implementation of MR imaging protocol and image processing pipelines, hiring and training research personnel. The project got permission to enroll participants in 05/18. Since then 28 potential PNES patients have been screened and 1 PNES has been enrolled and has completed the assessments.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1063800

Entities

People

  • Susanne G Mueller

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Markers
  • Biomedical Research
  • Brain
  • Data Processing
  • Databases
  • Education
  • Employment
  • Epilepsy
  • Image Processing
  • Institutional Review Board
  • Management Personnel
  • Medical Personnel
  • Nervous System
  • Patent Applications
  • Pipelines
  • Professional Development
  • Training

Readers

  • Canadian European Scientific Immigration and Epilepsy Clearance Studies
  • Clinical Trial Research.
  • Systems Analysis and Design