Detection and Characterization of Treatment Emergent Neuroendocrine Prostate Cancer Using Hyperpolarized 13C Magnetic Resonance

Abstract

The goal of this proposal is to discriminate biologically divergent treatment-emergent neuroendocrine prostate cancer (NEPC) from advanced adenocarcinoma based on the metabolic profile of NEPC tumors and to use real-time changes in metabolism to monitor therapeutic efficacy by using novel hyperpolarized (HP)(sup 13)C metabolic imaging techniques. In the 1st year of funding, our major activities focused on collating preliminary studies for Aims 1 and 2 to establish feasibility. To this end for Aim 1, the probes (glutamine and acetate) were optimized for hyperpolarization technique and tested in cells and baseline TRMAP studies. Correlative measures of NEPC presence were developed using ELISA and serum enzyme activities in addition to IHC quantification. Furthermore preliminary metabolic profiling of TRMAP tumors showed altered substrate utilization with the onset of CRPC further strengthening our hypothesis of metabolic adaptations with treatment resistance.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1063802

Entities

People

  • Renuka Sriram

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Adenocarcinoma
  • Biomedical Research
  • Cancer
  • Data Acquisition
  • Detection
  • Diseases And Disorders
  • Glutamine
  • Imaging Techniques
  • Magnetic Resonance
  • Medical Personnel
  • Metabolism
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Resonance
  • Tissues

Fields of Study

  • Chemistry

Readers

  • Medical Imaging.
  • Oncology and Biomarker-Based Cancer Detection.
  • Prostate Cancer Biology.