Ethnic Disparity of Mitochondrial Peptides and Prostate Cancer Risk
Abstract
Mitochondrial-dysfunction is associated with prostate-cancer (PC). We hypothesized that differences in MDP-expression levels contributes to the elevated-risk of PC in Black men. Our project is testing the potential of MDPs as biomarkers for PC risk, both as circulating pre-diagnostic biomarkers and as surrogate mitochondrial genetic risk indicators in a group of Black and White men with and without PC. Our Specific Aims include 1) To confirm the association between SHLP2 levels and prostate cancer risk; 2) to determine the association between additional plasma MDPs and prostate cancer risk among Black and White men in a newly enrolled population; and 3) to determine the contribution of mitochondrial versus nuclear genetic-race, relative to self reported-race, to the MDP-PC-risk connection. We have succeeded in enrolling substantial numbers of patients of both ethnicities. Our data from year-1 of the project confirms that MDP levels are generally lower in plasma of PC patients. This study is the first to study racial differences in MDP levels and their effect on PC. MDP levels and mitochondrial genetic origin may serve as diagnostic biomarkers of PC. Moreover, this study may set the stage for future mitochondrial-related interventions in minority populations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1063804
Entities
People
- Adriana Vidal
- Hemal Mehta
- Junxiang Wan
- Pinchas Cohen
- Steven Freedland
Organizations
- University of Southern California