Blocking Tumor-associated Macrophages to Overcome Chemoresistance in Ovarian Cancer
Abstract
We hypothesize that M2 macrophages also support chemotherapy resistance by interacting with tumor-initiating cells. With this proposal, we aim to thoroughly investigate the influence of M2 macrophages on ovarian tumor-initiating cells. To do so, we will combine the chemotherapy drug paclitaxel with a CSF1R inhibitor to block M2macrophages. Using three models of ovarian cancer: a mouse model, a human cell line implanted into mice, and samples of human ovarian cancer implanted into mice, we will study M2 macrophages and tumor-initiating cells during chemotherapy treatment. We will further explore how interactions between M2 macrophages and tumor-initiating cells support chemoresistance by disrupting M2 macrophages with CSF1R inhibition. We expect that combination therapy of CSF1R inhibition and paclitaxel will render the ovarian tumor-initiating cells more sensitive to chemotherapy treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2018
- Accession Number
- AD1063815
Entities
People
- Lily Wu
Organizations
- University of California