Novel Strategies to Improve Immunomodulation and Non-Invasive Clinical Monitoring in VCA

Abstract

Safely minimizing the risks associated with vascularized composite allotransplantation (VCA) is crucial for functional restoration of wounded warriors. Our overarching goal is enabling functional and aesthetic restoration to patients with severe, unreconstructable vascularized composite tissue defects by safe VCA protocols with minimal side effects. Our specific aims are: (1) Establishing the efficacy of a low-dose IL-2 protocol at enabling minimization of immunosuppression to sirolimus monotherapy in recipients of VCA. (2) Exploring correlations between cellular and molecular immunoassays performed in specimens from VCA recipients (and their donors) with clinical observations of stability and rejection. In future trials, these assays can be developed into tools that prospectively predict rejection and tolerance in VCA, and (3) Implementing next-generation methods to supplement and potentially overcome limitations of established methods such as histology and ultrasound biomicroscopy (UBM).

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1063838

Entities

People

  • Bohdan Pomahač

Tags

DTIC Thesaurus Topics

  • Abdomen
  • Allografts
  • Biomedical Research
  • Casualties
  • Composite Materials
  • Demographic Cohorts
  • Department Of Defense
  • Health Services
  • Hospitals
  • Immunomodulation
  • Immunosuppression
  • Monitoring
  • Pain
  • Quality Of Life
  • Rejection
  • Therapy
  • Transplants

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Oncology and Biomarker-Based Cancer Detection.