The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia

Abstract

Acquired aplastic anemia (AA) is a condition of bone marrow failure (BMF) characterized by blood pancytopenia and BM hypoplasia. In most cases, AA is an immune-mediated disorder with destruction of hematopoietic stem and progenitor cells by T cells. There is increasing evidence that CD4+ T effector cells that produce high levels of IFN- are associated with AA in patients and experimental AA mice. IFN- displays potent effects on suppressing hematopoiesis. Immunosuppressive therapy with antithymocyte globulin in combination with cyclosporin A (CsA) can induce a hematologic response in about two-thirds of AA patients. However, relapse occurs in up to 35% of AA patients when CsA is withdrawn at 6 months. Allogeneic BM transplantation (BMT) has significantly improved the survival of AA. However, graft-versus-host disease (GVHD) remains a major barrier to the success of the procedure. Novel approaches are needed to improve the outcomes of AA treatment.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2018
Accession Number
AD1063841

Entities

People

  • Yi Zhang

Organizations

  • Temple University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cells
  • Diseases And Disorders
  • Hematologic Diseases
  • Inhibition
  • Local Governments
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Molecules
  • Professional Development
  • Stem Cells
  • Survival
  • Transplantation

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech