Molecular Characterization of H. pylori Strains and Biomarkers in Gastric Cancer
Abstract
Helicobacter pylori (Hp) is linked to chronic gastritis, peptic ulcer disease (PUD) and gastric cancer (GC), but it is unknown why diverse gastric diseases develop in different Hpcarriers. GC annually claims 700,000 lives worldwide. GC early detection is vital in improving prognosis, but disease biomarkers are lacking. Our goal is to identify gastricepithelial cell (GEC) responses elicited by GC isolates that could represent candidate biomarkers and unique genomic features of those GC Hp isolates. We used novel human gastroid cultures infected with Hp isolates from diverse gastric diseases. In the first year report we highlighted that infections with different Hp isolates showed by real time PCR distinct expression by GECs of genes related to immunity, NOTCH signaling, metaplasia, cell survival and cell death. In the last year, we examined in depth those results and performed focused studies on the effects of those different GEC responses on the activation of CD4 T cells cocultured with Hp-infected GECs, since Hp subverts host immunity and that may affect tumor immune surveillance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2018
- Accession Number
- AD1063848
Entities
People
- Victor E. Reyes
Organizations
- University of Texas Medical Branch