Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients Using Turbo Cosubstrate

Abstract

During this period, we have demonstrated that 2-oxoglutarate (2OG) analogs can dramatically enhance the activity of TET2 enzymes from MDS patient. Further, so far we have published three manuscripts describing the results generating using this funding. Finally, we have identified novel substrate specificity of TET2 oxygenase. I hope these results will further generate 3-5 more publications in future.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1063867

Entities

People

  • Mridul Mukherji

Organizations

  • University of Missouri–Kansas City

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Detection
  • Genetics
  • Health Services
  • Hematologic Diseases
  • Liquid Chromatography
  • Mass Spectrometry
  • Medical Personnel
  • Neoplasms
  • Stem Cells
  • Students
  • Substrate Specificity
  • Vitamin C

Fields of Study

  • Biology
  • Computer science
  • Medicine

Readers

  • Analytical Chemistry
  • Molecular and genetic basis of cancer.
  • Technical Research and Report Writing.