The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

Abstract

The purpose of this study is to identify the mechanisms whereby the bone marrow microenvironment is involved in the regulation of tumor dormancy. Aim1 will identify and explore how disseminated tumor cells (DTCs) stay dormant for long periods of time. We postulate that DTCs drive the bone marrow niche into dormancy through the GAS6 pathway. Aim2 will determine how DTCs escape dormancy, consequently rendering them more susceptible to the chemotherapy. During this period, we found that a slow growing prostate cancer may contribute to proliferation of osteoblastic niche through bone morphogenetic protein (BMP)7. In addition, we observed that a fast growing osteoblast has ability to form bone more than a slow growing osteoblast, and that a fast growing osteoblast express less stem cells factor (SCF).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1063868

Entities

People

  • Yusuke Shiozawa

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Medical Personnel
  • Orthopedics
  • Pain
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells

Readers

  • Data Mining and Knowledge Discovery.
  • Immunology and Pathology

Technology Areas

  • Biotechnology