Probing Biotic/Abiotic Interfaces at the Nanoscale using Limited Proteolysis and Chiral Plasmonics

Abstract

The ultimate goal of the project is to acquire a better understanding of biotic/abiotic interface at the nanoscale that enables us to precisely engineer the interface between a biomolecule and a synthetic nanostructure, leading to rapid advances in the field of bio/nano hybrids. We investigated the influence of size, curvature and charge of the nanostructures on the structure and biocatalytic activity of bionanoconjugates. The structure and biocatalytic activity of the enzyme was found to be highly dependent on the charge and surface curvature of the nanostructures.

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Document Details

Document Type
Technical Report
Publication Date
Oct 09, 2018
Accession Number
AD1063900

Entities

People

  • Srikanth Singamaneni

Organizations

  • Washington University in St. Louis

Tags

Communities of Interest

  • Advanced Electronics

DTIC Thesaurus Topics

  • Air Force Research Laboratories
  • Biomolecules
  • Chemical Synthesis
  • Chemistry
  • Materials
  • Materials Laboratories
  • Materials Processing
  • Materials Science
  • Materials Testing
  • Mechanical Properties
  • Nanostructures
  • Optical Properties
  • Point-Of-Care Diagnostic Testing
  • Spectra
  • Spectroscopy
  • Surface Chemistry
  • Surface Plasmon Resonance

Fields of Study

  • Physics

Readers

  • Molecular and Cellular Biochemistry
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Microelectronics