Periodontal Intrabony Defect Regeneration: Accell Connexus (registered trade mark) Versus Demineralized Freeze-Dried Bone Allograft

Abstract

Introduction: Guided tissue regeneration with demineralized freeze-dried bone allograft (DFDBA) and a barrier membrane predictably improves clinical parameters in intrabony defects. Accell Connexus(AC) is a grafting material composed of DFDBA blended with DFDBA processed for rapid growth factor release and a polymer putty. Purpose: This randomized, double-blinded study compared AC to DFDBA for periodontal regeneration in intrabony defects when used with a resorbable collagen membrane. Methods: 25 subjects were enrolled and randomly assigned to receive AC or DFDBA for treatment of an intrabony defect. Probing depth and clinical attachment level changes were measured using custom stents at baseline, 6 and 12 months. Results: 20 subjects completed the study. Both AC (n=10) and DFDBA (n=10) groups improved significantly after treatment with no between-group differences for probing depth reduction or clinical attachment gain. Conclusion: Periodontal regeneration with Accell Connexus is comparable to DFDBA for probing depth reduction and clinical attachment level gain.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2017
Accession Number
AD1063968

Entities

People

  • Rachel V. Dulebohn

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Allografts
  • Anti-Bacterial Agents
  • Bone And Bones
  • Bone Diseases
  • Cells
  • Collagen
  • Connective Tissue
  • Growth Factors
  • Guided Tissue Regeneration
  • Materials
  • Mouth Diseases
  • Orthopedic Surgical Procedures
  • Osteogenesis
  • Peptide Growth Factors
  • Surgery
  • Teeth
  • Tooth Diseases

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.