Macrophage Responses to Epithelial Dysfunction Promote Lung Fibrosis in Aging
Abstract
Aim 1 and 2: Using mouse models of lung injury, fibrosis and epithelial dysfunction, we have demonstrated that microenvironment is a key factor driving phenotype of profibrotic alveolar macrophages. We have shown that epithelial dysfunction promotes recruitment of monocyte-derived alveolar macrophages and leads to exaggerated pulmonary fibrosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1064005
Entities
People
- Alexander V. Misharin
- Scott Budinger
Organizations
- Northwestern University