Brain Consequences of Spinal Cord Injury with and without Neuropathic Pain: Translating Animal Models of Neuroinflammation Onto Human Neural Networks and Back
Abstract
This project aims to investigate the consequence of spinal cord injury with regards to alterations in brain network function and expression of activated microglia, both human patients and in an animal model. During year three we have continued our collection of PET-MR data on spinal cord injured subjects, completed the rodent spinal cord injury surgeries and imaging procedures. Human imaging data is of consistently high quality and is reliably collected, albeit with some concerns regarding patient recruitment being slower than anticipated. The animal behavioral and imaging data is of high quality, and histological analysis is ongoing in parallell with neuroimaging analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1064012
Entities
People
- Nils C. Linnman
- Teng Yang
Organizations
- Boston Children's Hospital