Glutamate Neuroexcitotoxicity in GWI

Abstract

The objective of the proposed research is to examine whether dietary exposure to food additives containing glutamate may be contributing to symptoms in Gulf War Illness (GWI). The rationale for proposed study comes from data in the fibromyalgia field which suggests that reducing the consumption of dietary glutamate can reduce over-excitation in the nervous system, leading to symptom improvement. Since there is almost complete symptom overlap between fibromyalgia and GWI, it is of utmost importance to test this diet as a low-cost treatment option in GWI patients. Thus far, we have enrolled 16 subjects into the study and have 4 more people scheduled for their initial visit in the upcoming months. Overall, we are still on pace to recruit a total of 40 subjects in the timeline indicated in our SOW.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1064023

Entities

People

  • Kathleen F Holton

Organizations

  • American University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Contracts
  • Department Of Defense
  • Electronic Mail
  • Food Additives
  • Glutamates
  • Information Operations
  • Nervous System
  • Patent Applications
  • Persian Gulf Syndrome
  • Professional Development
  • Recruiting
  • Standards
  • Students
  • Technology Transfer
  • Universities

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