Repair of Traumatized Muscle Tissue for Improvement of Musculoskeletal Healing

Abstract

We are pursuing how skeletal muscle autografting improves muscle function and bone healing in a swine model of a segmental bone defect. Minipigs have been subjected to a 25mm diaphyseal bone defect in the mid-tibia stabilized with double plating and a customized scaffold. Experimental animals have an adjacent 7.0 g muscle defect. Functional muscle testing is performed monthly until sacrifice with a customized testing machine. We have had a reaction to our scaffold resulting in nonunions in the control animals. We are repeating the control animals with the isolated bone defect by eliminating the scaffold. The experimental design will continue once the control group has been successfully re-established.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1064048

Entities

People

  • Todd O McKinley

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Animals
  • Bone Fractures
  • Data Acquisition
  • Data Analysis
  • Databases
  • Diseases And Disorders
  • Information Science
  • Medical Personnel
  • Muscles
  • Muscular Diseases
  • Professional Development
  • Skeletal Muscle
  • Students
  • Test Methods
  • Tissues

Readers

  • Trauma Surgery or Emergency Medicine.