Long-Term Followup of the Delayed Effects of Acute Radiation Exposure in Primates

Abstract

This program studies the mechanisms and consequences of delayed effects of acute radiation exposure (DEARE) in non-human primates (NHP), with complementary mechanistic and therapeutic studies in mice. The program consists of 4 projects, focused on: 1. Type 2 diabetes mellitus (T2DM); 2. Radiation-induced heart disease (RIHD); 3. Chronic immune impairment; and 4. Genomics and transcriptomics. Major findings include peripheral microvascular and bioenergetic abnormalities in NHP with T2DM; restrictive myocardial fibrosis in RIHD; dose and age-dependent immune impairment; and ongoing sequencing work which will inform us regarding the molecular pathogenesis of T2DM, RIHD, and immune impairment in the context of DEARE.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1064640

Entities

People

  • J M Cline

Organizations

  • Wake Forest School of Medicine

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Lymphocytes
  • Medical Personnel

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.
  • Underwater engineering and Marine Technology.