Tumor Slice Culture: A New Avatar in Personalized Oncology

Abstract

The goal of this research is to advance our ability to precisely tailor therapy for solid tumors based on an ex-vivo TSC platform as a novel avatar of personalized oncology. The age of genomic medicine has brought tremendous hope to cancer patients, but the way in which this information gets translated to a clinical decision represents a major knowledge gap facing the oncologist. We now know that tumors with the same genetic mutation can have highly variable responses to targeted therapy. The lack of a functional assay with a quick turnaround time is the Achilles heel of personalized oncology. The objective of this proposal is to establish a robust, efficient, reproducible platform to interrogate drug sensitivity and to correlate the results with clinical and molecular data.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1064645

Entities

People

  • Qiang Tian

Organizations

  • Institute for Systems Biology

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Colon Cancer
  • Computational Biology
  • Confocal Microscopy
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Platforms
  • Sensitivity
  • Standards
  • Systems Biology

Fields of Study

  • Medicine

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Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech