Arylimidamide Azole Combinations against Leishmaniasis
Abstract
In vitro IC50's were determined for seventeen newly synthesized compounds. Most compounds showed high therapeutic indexes by displaying strong in vitro efficacy against L. major and L. donovani parasites but low in vitro toxicity when tested in a macrophage cell line. During the fourth (and last year) of this grant no compounds were tested in the in vivo models of cutaneous leishmaniasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2018
- Accession Number
- AD1064683
Entities
People
- Brian Vesely