Assessment of a Therapeutic Device for Treatment of Acute Lung Injury Using a Combat-Relevant Porcine Model
Abstract
Purpose. Acute lung injury (ALI) is recognized in >30% of combat casualties. Inflammation is a key component in ALI and therapeutic strategies to block inflammation are expected to decrease morbidity/mortality. Investigations directed at ways to limit activation and tissue accumulation of leukocytes at sites of inflammation may prove to be clinically effective. Scope/Aims. Specific approaches directed to target neutrophil and monocyte/macrophage activity, the effector cells of the innate immune system, may be a novel approach to diminish inflammation-induced disease processes without interfering with other immunologic activity, thereby avoiding adverse side effects. Innovative BioTherapies has developed an approach, known as selective cytopheretic device (SCD) therapy (Rx), in an effort to address this large unmet medical need.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2018
- Accession Number
- AD1064816
Entities
People
- Angela Westover
- Christopher Pino
- Deborah A Buffington
- H. D. Humes
- Jeffrey Curtis
- Kimberly A Johnston