A Pilot Study of Molecular Neuroimaging of Cerebral Blood Flow Abnormalities due to Traumatic Brain Injury (TBI) in a Swine Model (Sus scrofa)
Abstract
Objective: To determine whether there are changes in cerebral blood flow in the setting of acute traumatic brain injury. Materials and methods: A dose of Tc-99m-HMPAO tracer was administered to one sus scrofa, without a controlled cortical impact (CCI) and this subject was imaged on SPECT-CT. A second dose of Tc-99m_HMPAO tracer was administered in a subject with a CCI, which was then imaged with SPECT-CT. Results: The subject without a CCI SPECT-CT demonstrated a normal CT appearance of the brain and symmetric blood flow. The subject with a CCI SPECT-CT demonstrated post-craniotomy changes and no structural changes (i.e., no intracranial hemorrhage) and asymmetrically decreased blood flow to the injured brain. Conclusions: In this limited study, the traumatic brain injury was found to have decreased blood flow acutely, which can be imaged with SPECT-CT. This is consistent with the literature where decreased blood flow has been documented on CT Perfusion examinations. SPECT-CT represents a potential for improving diagnosis of blood flow changes in the setting of traumatic brain injury by capturing early blood flow changes post-TBI (i.e., via early administration of the radiotracer shortly after the TBI) or providing the potential to image certain patients who cannot have CT Perfusion (e.g., allergy) or MRI perfusion (e.g., contraindication to MRI).
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 07, 2018
- Accession Number
- AD1065185
Entities
People
- David Douglas
Organizations
- David Grant USAF Medical Center