In Vitro Dermal Absorption Proficiency Demonstration

Abstract

The dermal absorption of the three reference substances, benzoic acid, caffeine, and testosterone, was tested as a demonstration of technical proficiency. Reference substances were tested under infinite-dose conditions using the EpiDerm(TM) (EPI-606-X) RHE model and results compared to published validation studies. Permeation rates were in good general agreement with the results reported in the validation study. The performing lab is therefore technically proficient in performing the in vitro dermal absorption assay and may routinely use this assay for in vitro prediction of skin absorption.

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Document Details

Document Type
Technical Report
Publication Date
Feb 08, 2019
Accession Number
AD1067469

Entities

People

  • Emily M. Lent

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

DTIC Thesaurus Topics

  • Absorption
  • Agreements
  • Benzoic Acids
  • Caffeine
  • Calibration
  • Demonstrations
  • Epidermis
  • Health
  • Information Science
  • Public Health
  • Steady State
  • Test And Evaluation
  • Test Methods
  • Testosterone
  • Tissues
  • Toxicity
  • Validation

Readers

  • Computational Modeling and Simulation
  • Instructional Design and Training Evaluation.
  • Toxicology/Environmental Toxicology