Detection of Immunoglobulin E with a Graphene-Based Field-Effect Transistor Aptasensor

Abstract

DNA aptamers have the ability to bind to target molecules with high selectivity and therefore have a wide range of clinical applications. Herein, a graphene substrate functionalized with a DNA aptamer is used to sense immunoglobulin E. The graphene serves as the conductive substrate in this field-effect-transistor-like (FET-like) structure. A voltage probe in an electrolyte is used to sense the presence of IgE as a result of the changes in the charge distribution that occur when an IgE molecule binds to the IgE DNA-based aptamer. Because IgE is an antibody associated with allergic reactions and immune deficiency-related diseases, its detection is of utmost importance for biomedical applications.

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Document Details

Document Type
Technical Report
Publication Date
Jul 22, 2018
Accession Number
AD1069134

Entities

People

  • Ke Xu
  • Michael A. Stroscio
  • Min Choi
  • Mitra Dutta
  • Peter J Burke
  • Saadia Ranginwala
  • Sidra Farid
  • Xenia Meshik
  • Yi Lan
  • Yung Y. Wang

Organizations

  • University of Illinois at Chicago

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Charge Carriers
  • Chemical Engineering
  • Chemical Vapor Deposition
  • Chemistry
  • Detection
  • Detectors
  • Electronic Components
  • Engineering
  • Field Effect Transistors
  • Materials
  • Materials Science
  • Microscopes
  • Molecules
  • Proteins
  • Semiconductors
  • Transistors

Fields of Study

  • Biology

Readers

  • Allergy and Immunology.
  • Molecular Genetics
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology
  • Microelectronics