Establish and Characterize an Oral Opioid Self-Administration Model
Abstract
Non-medical opioid use has reached epidemic proportion in the United States. Due to the nature of the work, many service members may be vulnerable to developing opioid use problems. Animal models have already provided valuable information about the reinforcing effects of opioids; however improving animal models to better reflect aspects present in human use and could help us better understand, prevent, and treat this problem. Thus, we developed an animal model of opioid use that has better face validity (oral rather than intravenous opioid delivery, as is found in many cases of non-medical prescription opioid abuse) and incorporates alternative reinforcement, which is ever present and likely important in mitigating opioid abuse in humans, but which is rarely incorporated in to animal models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2018
- Accession Number
- AD1069362
Entities
People
- Bret Ginsburg
- Sandra Valtier
Organizations
- 59th Medical Wing