Characterization of SWRI 80A Reactivation of Recombinant Human Acetylcholinesterase and Identification of Its Absolute Chirality Using Specific Rotation Calculations in Gaussian/16 at the Hartree-Fock Level of Theory

Abstract

The United States Army Medical Research Institute of Chemical Defense (USAMRICD) in collaboration with the Southwest Research Institute (SwRI) has identified an uncharged reactivator of nerve agent-inhibited recombinant human acetylcholinesterase (rHuAChE) that was able to reactivate rHuAChE inhibited by GF (cyclosarin) by 90 within 5 minutes at a concentration of 500 M during in vitro testing. The oxime reactivator SwRI_80A (80A) was synthesized by SwRI and tested at the USAMRICD. 80A is a racemic mixture of isomers about a chiral carbon atom in a hexyl ring. Each isomer has two E-Z enantiomers about a carbon-nitrogen double bond near the reactivating oxygen on the oxime arm of the molecule. To evaluate the reaction kinetics of each isomer, the racemic mixture was separated on a super-critical-fluid chromatography system. Two peaks were identified and named by the elution order (P1 and P2). This report describes the identification of the chirality of those two peaks.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2018
Accession Number
AD1069425

Entities

People

  • Karen Brecht
  • Richard E. Sweeney
  • Shane A. Kasten

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Air Platforms
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Basic Programming Language
  • Biomedical Research
  • Chemistry
  • Computational Science
  • Department Of Defense
  • Energy Levels
  • Enzymes
  • High Performance Computing
  • Isomers
  • Measurement
  • Molecular Dynamics
  • Molecules
  • Nerve Agents
  • Nitrogen
  • Spreadsheet Software
  • Synapses

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