The Development of Nitroxide-Containing Anti-Biofilm Agents

Abstract

The goal of the project was to develop novel nitroxide-based anti-biofilm agents by incorporating nitroxides into the structures of antibiotics and biocides and which can then be attached to polymer scaffolds using various tethering approaches. The Fluoroquinolone-nitroxide hybrid compounds were prepared and tested for their anti-biofilm properties as well as their use as fluorescent probes. This grant award also had a collaboration with researchers from the Air Force Research Laboratory. The PI has had 2 peer reviewed papers, and 6 conference presentations and 2 manuscripts submitted as a direct result of the grant.

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Document Details

Document Type
Technical Report
Publication Date
Feb 05, 2019
Accession Number
AD1069453

Entities

People

  • Kathryn Fairfull-Smith

Organizations

  • Queensland University of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Bacteria
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fungi
  • Infection
  • Military Research
  • Small Molecules
  • Standards
  • Staphylococcus Aureus
  • Teamwork
  • Universities

Readers

  • Microbial Pathology
  • Molecular and Cellular Biochemistry
  • Research Science/Academic Research

Technology Areas

  • Biotechnology