Entropy Gives Rise to Topologically Associating Domains
Abstract
We investigate chromosome organization within the nucleus using polymer models whose formulation is closely guided by experiments in live yeast cells. We employ bead-spring chromosome models together with loop formation within the chains and the presence of nuclear bodies to quantify the extent to which these mechanisms shape the topological land scape in the interphase nucleus. By investigating the genome as a dynamical system, we show that domains of high chromosomal interactions can arise solely from the polymeric nature of the chromosome arms due to entropic interactions and nuclear confinement. In this view, the role of bio-chemical related processes is to modulate and extend the duration of the interacting domains.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 02, 2016
- Accession Number
- AD1069464
Entities
People
- Caitlin Hult
- David Adalsteinsson
- Josh Lawrimore
- Kerry Bloom
- Mark G. Forest
- Paula A. Vasquez
Organizations
- University of South Carolina